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Patients with a Migraine AttackA migraine attack does not affect the pharmacokinetics of rizatriptan.
Following oral administration of 14 C-labelled rizatriptanrizatriptan accounts for about 17of circulating plasma radioactivity.
Rizatriptanshould not be given to patients with ischemic or vasospastic coronary artery diseaseThere have been rare reports of serious cardiac adverse reactionsincluding acute myocardial infarctionoccurring within a few hours following administration of rizatriptanSome of these reactions occurred in patients without known coronary artery diseaseCAD5-HT1 agonistsincluding rizatriptanmay cause coronary artery vasospasmPrinzmetal’s Anginaeven in patients without a history of CAD.
Serious cardiac eventsincluding some that have been fatalhave occurred following use of 5-HT 1 agonistsThese events are extremely rare and most have been reported in patients with risk factors predictive of CADEvents reported have included coronary artery vasospasmtransient myocardial ischaemiamyocardial infarctionventricular tachycardia and ventricular fibrillation.
Factors that trigger this headache type are a muscle strainstress or anxiety.
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