Immunosuppressant therapy prednisone; azathioprine imuran ; cyclophosphamide cytoxan ; cyclosporine sandimmune ; mycophenolate mofetil cellcept .
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Using Imuran for a long time may increase your risk of skin cancer and lymphomaLymphoma is a cancer that affects your immune cells.
Imuran tablets are used as an immunosuppressant antimetabolite either alone ormore commonlyin combination with other agentsusually corticosteroidsand procedures which influence the immune responseTherapeutic effect may be evident only after weeks or months and can include a steroid-sparing effectthereby reducing the toxicity associated with high dosage and prolonged usage of corticosteroids.
Evidence of the teratogenicity of Imuran in man is equivocalAs with all cytotoxic chemotherapyadequate contraceptive precautions should be advised when either partner is receiving Imuran.
There have been reports of premature birth and low birth weight following maternal exposure to azathioprineparticularly in combination with corticosteroidsThere have also been reports of spontaneous abortion following either maternal or paternal exposure.
Azathioprine and/or its metabolites have been found in low concentrations in foetal blood and amniotic fluid after maternal administration of azathioprine.
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